About

Fighting cancer through the science of DNA replication gaps

Our Mission

To empower precision oncology by
revealing critical DNA replication gaps in cancer cells. We
envision a future where every cancer patient’s treatment is
guided by the unique DNA repair profile of their tumor,
leading to more effective and individualized therapies.

GapScore: Origins and Vision

GapScore was born out of cutting-edge research into DNA
replication stress and cancer vulnerability. A team of
oncology researchers and molecular biologists came
together with a bold idea: what if the gaps left during DNA
replication could predict how a cancer will respond to
treatment? Discovering that unrepaired replication gaps
are a core vulnerability in certain tumors, the founders of
GapScore set out to turn this insight into a real-world
diagnostic. They secured initial research funding and
demonstrated that a ‘Gap Score’ assay could differentiate
chemo-sensitive cancers from resistant ones. Encouraged
by early results, the team spun out of their academic labs
to form GapScore, with the goal of bridging the gap
between genomic discovery and patient care.”